four genes, namely CLOCK, Period, Cryptochrome and BMAL1. It is the work of these genes (their respective proteins) that help us maintain our circadian rhythm. When a take a flight through different time zones, these genes take a while to adjust to new environs and this is why we experience ‘jet-lag’. But researchers Rui Ye and Aziz Sancar at the University of North Carolina, were able to show that CLOCK and BMAL1 were the most important genes needed to maintain our circadian rhythms. Now, that we know how the clock works, we can design drugs that can help us to set the clock quicker or later as we need and get into routine quickly.